Faq
Twitch User Info
How do I get the profile picture or most recent game of a Twitch user?
Those variables are being populated by the Get User Info For Target subaction (Twitch -> User). For Source Type you can then choose between different sources. User is the one who redeems the trigger (e.g. the one who follows on a Follow trigger or uses the command on a Command Triggered trigger). From Input uses the %rawInput% as the target, so the command !command nate1280 would populate the variables for user nate1280. Just make sure the command location is set to Start in its settings. You can also choose Variable and type a variable like %randomUser0% in there if you have a preceding Add Random Viewer subaction.